MyBioSource.com's MDR3 P-glycoprotein (Multidrug Resistance Protein 3, ABC21, ATP-binding Cassette Sub-family B (MDR/TAP) Member 4, ABCB4, GBD1, PFIC-3, P-glycoprotein 3, PGY3) is a Mouse monoclonal antibody. The MDR3 P-glycoprotein (Multidrug Resistance Protein 3, ABC21, ATP-binding Cassette Sub-family B (MDR/TAP) Member 4, ABCB4, GBD1, PFIC-3, P-glycoprotein 3, PGY3) Antibody was generated using ABCB4, MDR2, MDR2/3, and MDR3 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function